Wistar-Led Team Awarded More Than $12 Million Grant from the NCI to Investigate Link Between Epstein-Barr Virus and Carcinomas

PHILADELPHIA, PA, July 26, 2023 (GLOBE NEWSWIRE) — It's been known since the 1960s that Epstein–Barr Virus (EBV) causes a variety of cancers, but research has overwhelmingly focused on its connection to lymphomas. Now, a multidisciplinary team of scientists led by The Wistar Institute has been awarded a more than $12 million National Cancer Institute (NCI) Program Project Grant (P01), a highly competitive five–year grant that includes a crosssection of researchers from various disciplines and institutions throughout the country. The multidisciplinary team led by Wistar scientists is exploring the role of Epstein–Barr Virus in epithelial cancers. Epithethelial cells form functional structures in organ tissue throughout the human body; they are often the site for solid organ cancers, including the most common cancers, which are known as carcinomas.

The new research will focus on basic questions about how EBV infection of normal epithelial cells transforms them into cancer–cells. Scientists also intend to build on this research to identify better and more selective therapeutic targets.

"We are investigating unexplored aspects of EBV and malignancies, potentially uncovering unique characteristics or pathways that can be targeted for therapeutic intervention," said Italo Tempera, Ph.D., associate professor of the Gene Expression & Regulation Program of the Ellen and Ronald Caplan Cancer Center at The Wistar Institute. "This fresh perspective could lead to groundbreaking discoveries and innovative treatment strategies for EBV and epithelial malignancies."

The project brings together scientists from The Wistar Institute and Harvard University, including experts in epigenetics, metabolomics and drug discovery. It's the first time researchers from this variety of disciplines have combined their efforts to focus entirely on the EBV–epithelial cancer link.

"We've put together a new strategy, a new way of attacking the problem," said Paul Lieberman, Ph.D., Hilary Koprowski, M.D., Endowed Professor and director of the Center for Chemical Biology and Translational Medicine at Wistar. "By working together across different modalities, there's an opportunity for each of us to learn from the synergy and expertise of the other investigators."

EBV is one of the most common human viruses, infecting an estimated 95% of people by the time they reach adulthood. Symptoms are usually mild, and most people recover within a few weeks. However, the virus can remain latent in the human body for years or even decades, and it causes some people to develop cancer later in life.

While research has historically focused on lymphomas, EBV–linked epithelial cancers are both more common and more deadly. Epithelial cancers represent 75% of the 200,000 EBV–related cancer cases diagnosed each year, and these cancers also have higher mortality rates and treatment failures.

"This grant put together a team that is now focused on this type of cancer that has been neglected, even though it's the most common form of EBV cancers," Lieberman said. The grant will fund three main research projects. The first will look at how EBV establishes a long–term infection within epithelial cells. The second will study how it causes genetic and metabolic changes to trigger cancer growth. Finally, researchers will use these findings to investigate new therapeutic strategies.

The research builds on past work by Lieberman's lab, which has focused on developing small molecule inhibitors targeting EBV. He said the new project would focus on studying drugs that are already in development, and looking for ways to make them more targeted or use them in combination with other therapies.

Tempera said the group's integrated approach sets it apart."Our project will study both metabolic and epigenetic vulnerabilities simultaneously," he said. "Combining these two aspects can provide a comprehensive understanding of the role of EBV infection in cancer and its underlying mechanisms, leading to unique insights and therapeutic opportunities."

Co–authors: Ben Gewurz of Harvard; Joseph Salvino, Samantha Soldan, Andrew Kossenkov, Louise Showe, and Qin Liu of Wistar.

GLOBENEWSWIRE (Distribution ID 8881269)

ChainSys Corporation Achieves SELECT Partner Status with Snowflake

ROCKLIN, Calif., July 26, 2023 (GLOBE NEWSWIRE) — ChainSys Corporation, a leading global data management platform provider, announced today that it has achieved SELECT LEVEL tier partner status from Snowflake, the Data Cloud company. This partnership enables ChainSys to offer joint customers accelerated digital transformation, leveraging Snowflake's performance, flexibility, and near–infinite scalability of the Snowflake Data Cloud.

ChainSys offers over 80% acceleration to data migration journeys to Snowflake Data Cloud from Hadoop, SQL, Oracle, and other legacy data warehouse solutions. With over 10,000+ readymade Smart Adapters, ChainSys can help customers migrate all types of data, including structured, unstructured, videos, audio, sensor data, and more. ChainSys and Snowflake can help customers analyze and curate data using the best AI/ML techniques, enabling organizations to become data–driven and mobilize the world's data with Snowflake's Data Cloud.

ChainSys offers several great benefits, including accelerating data extraction from all sources, migrating source data into the Snowflake Data Cloud with the highest speed, curating data to ensure its cleanliness and completeness, cataloging data to create active metadata management, analyzing and predicting useful facts for business growth, and monetizing data with high security and data governance in place.

"ChainSys combined with Snowflake's Data Cloud comprise a powerful combination of capabilities to streamline the entire Data Fabric and Data Mesh processes and mobilize data in the service of the enterprise."

"" Sundu Rathinam,
CEO "" ChainSys

ChainSys and Snowflake Use Case:

  • ChainSys and Snowflake offer a joint solution for data migration from various ERP systems (SAP), Oracle, Microsoft, etc.) into a common data model in Snowflake.
  • The solution includes an out–of–the–box option for the effortless transfer of legacy data warehouses like Hadoop, SQL, Oracle, and others to the Snowflake Data Cloud.
  • The migration process covers metadata, data, and ETL pipelines transfer.
  • Customers can apply data quality rules to harmonize master and transactional data as it reaches Snowflake schemas.
  • The solution provides an out–of–the–box option for active metadata management and capturing data lineage.
  • Data governance policies for data monetization and data exchange creation are also available.
  • ChainSys and Snowflake offer the best data engineering solution suitable for any enterprise.

The Snowflake Partner Network unlocks the potential of the Data Cloud with a broad array of tools and partners. Certified partnerships and integrations enable customers to leverage Snowflake's flexibility, performance, and ease of use to deliver more meaningful data insights. To become a Snowflake partner and get access to Snowflake's self–service partner resources, please click here.

"Partners, like ChainSys bring the needed acceleration to our customers, for data migration, data quality and data governance, and enable our customers to benefit from leading–edge technologies with valuable industry and business experience on Snowflake's single, integrated platform. We are eager to closely collaborate with ChainSys to bring newer innovations together and ensure our customers get even more value from Snowflake's Data Cloud."

"" Tarik Dwiek,
Head of Technology Alliances – Snowflake

ChainSys Corporation, founded in 1998 in Michigan, USA, currently has operations in the USA, Canada, Netherlands, UK, Middle East, India, and Singapore to support its global clients. The company's flagship Smart Data Platform provides a NO–CODE platform for end–to–end data management needs.

ChainSys Data Management Platform:

ChainSys trains end–users for productivity improvement continuously, manages and maintains the enterprise data migration and data quality platform accommodating scalability and repeatability, offers high flexibility to accommodate all expectations, adheres to the SLA, and all security processes strictly.

ChainSys offers the best product, best processes, and best people for data migration and data quality projects. The company commits to the best practices in data migration and data quality management, delivering the best efficiency in data operations with simplified and complete closed–loop processes using data migration and data quality as the foundation, and implementing the best–of–breed solution for data migration and data quality requirements.

Customers Leveraging the Smart Data Platform:

ChainSys is excited to become a Snowflake partner and offer customers a trusted data partner for all their data migration and data quality needs. Don't miss the opportunity to experience the power of ChainSys and Snowflake's joint solution. Read More about ChainSys and Snowflake here!

"Together, ChainSys and Snowflake can provide every data leader in an organization with a unified data platform, as opposed to relying on the capabilities of multiple data systems and mastering the nuances of each."

"" Amarpal Singh Nanda,
President Enterprise Data Management – ChainSys

Contact information:

Caroline Anand, Senior Marketing Manager

Photos accompanying this announcement are available at

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