Conagen innovates novel natural-source retinol for cosmetic formulations

Bedford, Mass., Aug. 22, 2023 (GLOBE NEWSWIRE) — Conagen, the bioplatform innovator and biomanufacturer, has developed a first–of–its–kind, natural–sourced class of sustainable retinol derivative ingredients through precision fermentation. This achievement in new retinol active ingredients reshapes beauty and personal care applications.

"Conagen is ready to commercialize these retinoid ingredients in 2024," said VP of Flavors and Fragrances, Yisheng Wu, Ph.D. at Conagen. "Beauty and personal care brands seeking the newest technology in retinol formulation flexibility are encouraged to explore Conagen's retinoid ingredients."

Conagen's retinoids derivatives are created by covalently binding retinoids with another cosmetic active ingredient into a single molecule. The retinol is produced with a 100% renewable carbon source through the precision fermentation process. Through the fusion of retinol and a second complementary ingredient, the technology offers consumers functionalities that extend beyond wrinkle reduction and anti–aging benefits.

“This new development empowers cosmetic formulators to create products that excel in both performance and innovation, aligning with the ever–evolving demands of today's discerning consumers," said Wu. "By providing enhanced stability, controlled release, and multifunctional capabilities, Conagen's retinoid derivatives redefine the possibilities within the cosmetic industry."

A notable feature of Conagen's innovative retinoid variants is their adaptability. Depending on the selected partner for pipeline integration, these compounds introduce flexibility, enabling cosmetic formulators to incorporate a secondary function. This presents opportunities for inventive features that uniquely enhance cosmetic formulations.

Pushing the limits in creative beauty, Conagen's primary achievement lies in the improved stability these retinoid derivatives provide. This enhanced stability enables cosmetic products to ensure a consistent and extended release of retinol, resulting in long–lasting effects on the skin. Traditional retinol is known to cause skin irritation, such as redness, dryness, and peeling. Conagen's retinol ingredients aid in the formulation of low–irritation retinol products. These ingredients are compatible with other compounds, such as squalene, bakuchiol, and pomegranate extract, maximizing delivery and effectiveness while minimizing potential off–target effects.

According to Innova Market Insights, online consumer searches for retinol in beauty and personal care are rising. With approximately 1 million tags on Instagram and a growing trend, the demand for this anti–aging active ingredient continues to surge. Innova's global report highlights consumers prioritizing anti–aging and anti–acne properties in skincare, followed by blemish reduction.

The success of this retinol innovation originates from the unique high–yield carotenoid platform led by Wu, who has worked on the project for years. This meticulously studied platform has yielded numerous widely utilized carotenoid compounds, including beta–carotene and astaxanthin. By introducing additional steps in the metabolic pathway, Conagen can make retinol at high efficiency. This same versatile platform holds the potential to generate various flavors, fragrances, and nutritional compounds derived from carotenoids, further underlining its significance.

“Conagen's achievement underscores its steadfast commitment to pushing the boundaries of biotechnology and driving innovation," said Wu. "As the cosmetic industry undergoes transformation toward clean and sustainable, Conagen remains at the forefront of transformative advancements, poised to contribute to a new era in cosmetic formulation."

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About Conagen

Conagen is a product–focused, synthetic biology R&D company with large–scale manufacturing capabilities. Our scientists and engineers use the latest synthetic biology tools to develop high–quality, sustainable, nature–based products by precision fermentation and enzymatic bioconversion. We focus on the bioproduction of high–value ingredients for food, nutrition, flavors and fragrances, beauty, personal care, pharmaceutical, and renewable materials industries. www.conagen.com

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Vaccine Equality Is as Vital for Livestock as for People

PREVENT project in Tanzania/Iringa, 2021, Helena Kindole. Credit: Colin Dames/CEVA

By Enrique Hernández Pando
El Castellar, Spain, Aug 22 2023 – El Castellar – For 33-year-old mother-of-seven and poultry farmer Helena Kindole in Chanya village in Tanzania, one of the main barriers to growing her chicken business is a lack of access to health services. But not for herself or her family – for her animals.

With smallholder poultry farming often a lifeline for millions of low-income and rural families – accounting for 80% of poultry production in the region – access to medicines and vaccines is just as important for livestock as it is for people. And yet, logistical, infrastructural, and supply challenges are hindering access to veterinary services across the African continent and therefore, holding back smallholder productivity.

Enrique Hernández Pando

At the same time, a rapidly industrialising poultry sector in many developed countries, and an increase in grain prices globally, coupled with cheap imports from more developed markets and low access to animal health care is driving inequality between small- and large-scale producers, threatening to squeeze out smallholder poultry farmers.

Thankfully, this is starting to change. Animal health initiatives are helping local hatcheries to vaccinate chicks against common and damaging diseases before selling them to small-scale farmers, who rear the chicks until they are six months old, eventually selling them to neighbours, restaurants, and other businesses nearby.

For women like Helena, who make up nearly half of the global agricultural workforce in developing countries and in sub-Saharan Africa, the poultry sector offers a crucial source of income and healthy animals are essential for decent livelihoods.

Equipping farmers with the right tools can help to set them up for success to compete alongside more industrialised production systems.

Introducing vaccinations at local hatcheries can strengthen small-scale producers’ sustainability and commercial clout. Supporting these hatcheries with the necessary vaccination equipment and expertise means they can provide customers with large numbers of chicks that are vaccinated against common poultry diseases, such as Newcastle disease and Infectious bronchitis, the former of which contributes to 60% of poultry mortalities in many African countries. This reduces the risk of bird loss, contributing to improved income and more successful businesses overall.

Small-scale chicken farmer in Tanzania/Arusha, 2015. Credit: Karel Prinsloo/GALVmed

But implementing vaccination measures alone is not enough, as a lack of technical support and knowledge on zoonoses and other infectious diseases that affect poultry can also hinder productivity. Training on animal health practices, market development opportunities, and advice on biosecurity, good management practices, and more are also crucial pieces of the puzzle. Providing this can help to level the playing field between large scale, industrial hatcheries and small-scale producers.

The PREVENT project (Promoting and Enabling Vaccination Efficiently, Now and Tomorrow) is one example of an initiative working to improve poultry production for Africa’s rapidly growing population. In just two years, this four-year initiative has administered 159 million vaccine doses and vaccinated 49 million hatchery chicks. It has also trained 100 field technicians who have conducted 2,600 farm visits and held over 1,400 farmer meetings across four countries in sub-Saharan Africa, to date.

A low-input but high-producing sector, raising chickens offers a reliable pathway out of poverty for many rural households. A small-scale producer can easily sell their chicks or chickens at the market as they are more affordable for the consumer than beef, for example, but also bring a myriad of other benefits. They add value to social structures, are high in protein, and, on top of this, can directly benefit women who in fact make up the majority of smallholder poultry farmers in the developing world.

Small-scale chicken farmer in Tanzania/Arusha, 2015. Credit: Karel Prinsloo/GALVmed

Against the backdrop of a global cost of living crisis, record-breaking temperatures, and ongoing conflicts, closing the inequality gap for smallholder farmers is critical to build a sustainable future for all. Supporting small-scale producers with training, animal health measures, and much more can help to level the playing field, one small-scale producer at a time, just like Helena.

IPS UN Bureau

 


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Enrique Hernández Pando is Executive Director, Commercial Development & Impact, GALVmed

Qur’an Burning: Rage, Ignorance and Prejudice

By Anis Chowdhury
SYDNEY, Aug 22 2023 - Qur’an burning has become a symbol of intolerance and “Islamophobia”, especially in some Western countries. Following the public burning of a Quran in front of Stockholm’s largest mosque on June [...] Read more »