Conagen develops high-purity non-GMO sulforaphane by bioconversion

Bedford, Mass., Nov. 29, 2022 (GLOBE NEWSWIRE) — Expanding on its portfolio of innovative nutritional products through biotechnology, Conagen, announced the development of its 99% high–purity sulforaphane. Made by a proprietary bioconversion technology, the company plans to begin the commercialization path in 2023. Conagen's bioconversion methods enable the production of sustainable products from many naturally occurring compounds regardless of rarity or small quantities occurring in nature.

"As a supplement product, Conagen's high–purity sulforaphane is appealing to consumers as the levels found in raw vegetables are too low to realize many of its promising health benefits," said Casey Lippmeier, Ph.D., senior vice president of innovation. "We're looking forward to expanding the nutritional market by commercializing sulforaphane in 2023."

Sulforaphane has been associated with supporting health benefits against cancer, diabetes, digestion, and heart disease and promoting cognition. With biotechnology and biomanufacturing advancements, much like Conagen's bioconversion technology, more nutritional offerings are produced at a high–quality and global scale.

Sulforaphane is found in cruciferous vegetables such as arugula, bok choy, broccoli, Brussels sprouts, cabbage, kale, radish, and more. In these vegetables, the inactive form of glucoraphanin belongs to the glucosinolate family of plant compounds. The sulfur–rich sulforaphane is activated only when vegetables are chewed or chopped to release myrosinase, a class of enzymes that play a role in the defense response of plants.

"Through Conagen's bioconversion technology, we're uncovering the great potential in sulforaphane as a powerful active health ingredient for consumers who are personalizing nutrition to support health functions," said Lippmeier. "We can make safe and high–quality nutritional ingredients from natural sources and offer it at a global–scale cost–competitively so that brands may pass on the good health and savings to their consumers."

Conagen's sulforaphane is ideal for non–GMO supplement solutions to formulate products with a sustainable and natural consumer appeal. More research is emerging for understanding the optimistic effects on multiple health functions. As one example of many, biotechnology and biomanufacturing will continue to harness the power of biology and nature to develop and deliver solutions for better nutrition, health, and wellness. Conagen is expanding its sustainable, nutritional products portfolio to better humankind and the planet.

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About Conagen
Conagen is making the impossible possible. Our scientists and engineers use modern synthetic biology tools to program micro–organisms and enzymes on a molecular level to produce high–quality, sustainable, natural products manufactured worldwide via precision fermentation and bioconversion. We focus on the bioproduction of high–value ingredients for food, nutrition, flavors and fragrances, pharmaceuticals, and renewable materials.

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Vaccine Refusal, Floods Impact Polio Drive in Pakistan

A young child receives vaccine drops in Pakistan, but the region has experienced an upsurgence of cases because of vaccine refusal. Credit: Ashfaq Yusufzai/IPS

A young child receives vaccine drops in Pakistan, but the region has experienced an upsurgence of cases because of vaccine refusal. Credit: Ashfaq Yusufzai/IPS

By Ashfaq Yusufzai
PESHAWAR, Nov 29 2022 – Vaccine refusal is impacting the eradication of polio in Pakistan.

Pakistan has vaccinated about 35 million children during its door-to-door campaign, but about 500,000 remained unvaccinated due to refusal by their parents, Jawad Khan Polio officer in Khyber Pakhtunkhwa, recorded in 2022 so far.

Khyber Pakhtunkhwa, one of Pakistan’s four provinces, has reported all 20 polio cases. North Waziristan has detected 17 infections, Lakki Marwat 2 and South Waziristan 1.

Khan says that hesitancy against vaccination is not a new trend, as Pakistan has been facing this problem since the start of the polio-eradication campaign in the 90s.

Of the 17 cases reported in militancy-riddled North Waziristan, 12 were not vaccinated, while five were partially immunized.

Muhammad Shah, whose son was diagnosed with the polio virus in August, told IPS that he had been opposing vaccination because this wasn’t allowed in Islam.

“Our religion Islam says that no medication is permissible before the occurrence of any ailment; therefore, our people defy vaccination to fulfill their religious obligations,” he said. Shah, a religious preacher, says his son will soon recover from the paralysis.

He says he was unrepentant in refusing vaccination of his child and would continue to thwart efforts by vaccinators to inoculate the toddler.

North Waziristan district, located near Afghanistan’s border, has many militants who staunchly oppose vaccination.

“It was the hub of the polio virus till 2014 when militants ruled the area illegitimately as there was a complete ban on all sorts of immunization. The Taliban militants were evicted through a military operation in 2014, and parents started vaccinating their kids,” Sajjad Ahmed, a senior health worker, said.

According to him, polio vaccinations have decreased with the emergence of militancy in the area.

“In the last three months, three persons, including two policemen and one health worker, have been killed by unknown assailants during a polio drive in North Waziristan,” he said.

People are afraid to take part in the campaign due to fear of reprisals by Taliban militants, he said.

Dr Rafiq Khan, associated with polio immunization in the region, told IPS that parents refuse vaccination, arguing that it was a US and Western plot to render recipients impotent and cut the population of Muslims – a baseless argument.

“Alleged Taliban have killed about 70 vaccinators and policemen since 2012. Government deploys 25,000 policemen in each three-day campaign to ensure the safety of workers,” he said.

Khan said that militants are pressuring the people against vaccination, due to which parents weren’t willing to administer jabs to their kids below five years.

“We are also facing fake finger marking of kids. As a standard procedure, our vaccinators mark the thumb of the vaccine recipients with indelible ink so that we know how many children have been immunized,” he said.

However, the parents ask the vaccinators to mark their kids’ fingers without vaccination, he said. In this way, parents deceive the government.

“Now, we have started convincing the parents through community elders and religious scholars to create demand for vaccination,” he said.

The government has enlisted the services of religious scholars to do away with refusals against poliomyelitis.

Maulana Amir Haq, a pro-vaccination cleric, told IPS that they had been holding awareness sessions with people telling them vaccination is allowed in Islam.

“It is the responsibility of the parents to safeguard their kids against diseases and vaccination aimed to prevent the crippling ailments. There, parents should fulfill their religious duty and inoculate their sons and daughters,” he said.

He said that laboratory reports confirm vaccines given to Pakistan’s children are safe and don’t contain any ingredient to sterilise the recipients. The situation is changing because we now reach hardcore refusal cases and vaccinate them.

Federal Health Minister Abdul Qadir Patel said that it is crucial to understand that the only protection from polio is vaccination, and parents should protect their children against disability through free immunization.

“We want to wipe out the virus and safeguard not only our own kids but all around the world,” he told IPS.

Polio will keep haunting us until we interrupt transmission, Federal Health Secretary Dr. Muhammad Fakhre Alam said.

On August 31, a 16-year-old boy was diagnosed positive for polio in Waziristan, which shows how robust Pakistan’s virus detection network is because it highlights that we can identify polio cases in children outside the usually expected age, he said.

National Emergency Operations Centre Coordinator for polio, Dr Shahzad Baig, expressed concerns about the spread of wild poliovirus as millions of people in the country are displaced by recent floods.

“The scale of the current calamity is absolutely devastating. As part of the polio programme, our network of health workers is here to support in every way we can, but I am deeply concerned about the virus gaining a foothold as millions of people leave their homes and look for refuge elsewhere,” he said.

The province of Balochistan and parts of southern Punjab, and 23 districts of Sindh were unable to hold a vaccination drive as floods swept away homes and villages around the country. Despite the extreme climatic conditions, polio teams reached children in all accessible areas, he said.

Neighbouring Afghanistan is facing the same problems; however, it has detected only two cases this year.

IPS UN Bureau Report

 


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AGRA Gets Make-Up, Not Make-Over

By Timothy A. Wise and Jomo Kwame Sundaram
BOSTON and KUALA LUMPUR, Nov 29 2022 - Despite its dismal record, the Gates Foundation-sponsored Alliance for a Green Revolution in Africa (AGRA) announced a new five-year strategy in [...] Read more »